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EN
ENU mutagenesis induced a point mutation at the conserved serine at position 645 of the pseudokinase domain (p.Ser645Pro) corresponding to a somatic human mutation (p.Ser646Phe) inducing constitutive activation of the Janus Kinase/STAT pathway. (J:68708, J:199153)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
