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A human beta-globin locus control region HS2 (DNaseI hypersensitive site 2) fragment was linked upstream in tandem to an HBB transgene that has a lacZ cassette in place of the region from the initiation codon to the BamH1 site of the HBB gene sequence. Regulatory sequences of HBB are retained in the 5' flanking region, in IVS-2 (second intervening sequence), and 3' to the gene. 10 founder lines were produced, and line A (copy number of 57) which has high beta-galactosidase activity in the periperal blood. The ES cell line generated from this transgene carries the transgene on distal chromosome 4. (J:203044)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
