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Mice carrying a conditional Trp53 allele with a nonsense mutation in exon 10 were crossed to Tg(Pgk1-cre)1Lni mice to excise the floxed stop cassette. The resultant allele produces a Trp53 mRNA encoding a protein lacking the last 31 amino acids (the C terminal domain; CTD). (J:199308)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
