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An FRT flanked neomycin cassette followed by a loxP site was inserted in intron 2 and a second loxP site was inserted just downstream of exon 3. Exon 3 is flanked by loxP sites (1154 bp). The resistance cassette was then excised from properly targeted ES cells using flp recombinase and leaving exon 3 flanked by loxP sites. Remaining FRT site 30 bp 5 prime of the 5 prime loxP site (FRT-flanked NeoR cassette excised in vitro). (J:198636)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
