A short hairpin RNA directed against exon 8 of Ezh2 was targeted into the locus. The shRNA sequence is under the regulation of the H1/tetO operator fusion promoter and a codon-optimized tet repressor (itetR) driven by the CAGGS promoter. (J:202724)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count