A targeting vector was designed to insert loxP sites on either side of exon 2 followed by an FRT-flanked neomycin selection cassette. The neomycin resistance cassette was removed by Flpe-mediated recombination using mice carrying the Tg(CAG-Flpe)2Arte allele. (J:202737)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count