An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette and left exons 5 through 7 floxed. (J:199264)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count