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A 5 kb genomic fragment of Hoxa5 (containing the temporal (T) control region, the brachial spinal cord (BSC) enhancer, proximal Hoxa5 promoter, both exons and the intron of Hoxa5) drives cre epxression in this transgene. An IRES-EGFPcre cassette was inserted into exon 1 of Hoxa5 downstream of the translation initiation codon. A 2.1 kb fragment containing the mesodermal (MES) enhancer was added at the 3' end of the construct to produce the 7.1 Hoxa5/Cre transgene. Nine founder lines were obtained andLine 444C was established. This line has 2 copies of the transgene. (J:207917)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
