A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 4. An IRES-nlacZ was inserted into exon 6. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 4 floxed and the lacZ reporter intact. (J:200546)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count