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A modified human ACTA1 skeletal alpha-actin promoter (-2000 to +239drives muscle-specific expression of a dominant negative form of human TRPC6 cDNA in which three highly conserved amino acids (L678-W680) within the putative pore region were replaced with alanine residues. Line 1 was generated. (J:154908)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
