A loxP site was inserted in intron 1 just upstream of exon 2 and its start codon. An FRT flanked neomycin selection cassette followed by a second loxP site was also inserted in intron 3. Properly targeted chimeric mice were then bred to mice expressing flp recombinase leading to excision of the selection cassette. (J:197148)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count