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Homologous recombination in ES cells inserted a cre/ERT2-PGK-neo cassette into the Sox2 locus, generating a knockin allele that functionally is a null allele of Sox2. The frt-flanked neo marker was deleted by crossing animals with Tg(ACTFLPe)9205Dym mice. Lineage tracing in embryos from tamoxifen treated females of R26YFP and Sox2Cre/ERT2 intercrosses demonstrated labelled cells at P1 in tissues that normally express Sox2 (brain, eyes, ears, oral epithelia). (J:201265)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
