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A transgene composed of human CCR5 and CD4 on a single poly-protein transcript separated by a ribosomal skip 2A was placed downstream of thehuman ubiquitin C promoter. A linearized 4.5 Kb fragment containing the transgene was injected into C57BL/6J fertilized female pronuclei. Founder line 19 was chosen based on surface expression of hCD4 and hCCR5 on peripheral blood mononuclear cells as determined by flow cytometry. (J:200013)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
