LoxP sites were inserted flanking exon 2 and an FRT flanked neo cassette was inserted in intron 2. Properly targeted micd were then crossed to mice expressing flp recombinase to remove the selection cassette. (J:196137)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count