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A mouse bacterial artificial chromosome (BAC; RP24-95M11), containing the entire Phox2b (paired-like homeobox 2b) locus was obtained. This BAC also contained ~150kb sequence upstream of the Phox2b locus and ~50kb of sequence downstream of the Phox2b locus. A codon-optimized FLPo recombinase sequence fused with an SV40 polyadenylation signal, and a kanamycin resistance cassette were inserted into exon 2 of Phox2b. The resulting Phox2b::FLPo BAC transgene was injected into (C57BL/6 x DBA/2)F1 fertilized oocytes. (J:199321)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
