A targeting vector was obtained from the European knockout consortium (EUCOMM). The targeting construct contains a splice acceptor, beta-geo cassette flanked by two Flp sites preceding the third exon. In addition, the targeting construct introduced two loxP sites on either side of exon 3. Transient cre expression resulted in the excision of exon 3 while leaving the FRT flanked beta-geo intact. (J:188485)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
Insertion, Intragenic deletion
--
1
4
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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