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Recombinase mediated cassette exchange involving Gt(ROSA)26Sortm1Rkuhn introduced into the locus a CAG promoter, floxed stop cassette and a fusion of the mouse cDNA containing the amino acid substitution of glutamic acid for valine at position 673 and an N-terminus nuclear export signal to the modified estrogen receptor (ERT2). The mutation is equivalent to the human mutation V600E. (J:196873)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
