An FRT site, splice acceptor, EYFP, loxP site, neomycin resistance (neo) cassette, FRT site and loxP site were inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left the EYFP intact and exon 2 floxed. Immunohistochemistry confirmed the absence of protein expression in most interneurons in the brain. (J:198157)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count