A targeting construct containing the human GP6 cDNA coding sequence was introduced into exon 1 at the ATG start site. The human sequence was followed by a polyadenylation sequence and floxed neomycin resistance cassette. Cre-mediated recombination removed the neo cassette. (J:199351)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count