An FRT-flanked neomycin (neo) resistance cassette with a 5' loxP site was inserted upstream of exon 8. An additional loxP site was inserted into the 3' UTR in exon 9. Flp-mediated recombination removed the neo cassette and left the coding sequence in exon 8 and 9 floxed. (J:198847)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count