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A transgene designed to contain the human low-molecular weight exported 18-kDa isoform of FGF2, an internal ribosome entry site (IRES), and a blue shifted variant of GFP known as Sapphire under the control of a 3.6 kb fragment of the Col1a1 5' regulatory region (Col3.6). The construct also harbors a neomycin selection cassette. Founder line 305 was established. Western blot analysis demonstrates high levels of expression of 18-kDa FGF2 in femurs and calvariae, low levels of expression in liver, and no expression in other tissues. (J:147213)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
