Card11^M2Btlr

The causative mutation is a C to T transition at base pair 140876495 (v38) on Chromosome 5 in the GenBank genomic region NC_000071 encoding Card11. The mutation corresponds to residue 3367 in the mRNA sequence NM_175362 within exon 23 of 25 total exons. The mutation results in an arginine (R) to premature stop codon substitution at amino acid 1016. (J:198555) Additional incidental mutations were detected in sequencing for the causative mutation, Card11M2Btlr, and may be present in stocks carrying this mutation.