A loxP site was inserted upstream of the first coding exon. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of the first coding sequence. FLP-mediated recombination removed the neomycin resistance cassette and leave the first coding exon floxed. (J:197966)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count