Exons II, III and IV were flanked by loxP sites. An F3-flanked puromycin resistance cassette was inserted into intron IV. Mutant mice were mated with Flp transgenic animals to delete the puro marker to generated a floxed mouse line. (J:194965)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count