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The targeting construct inserted into the locus contained a CAG promoter that drives ubiquitous expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of glutamic acid for aspartic acid at position 250 (E250Q) preceded by a floxed STOP cassette and followed by an IRES and the truncated human CD2 tag. (J:196002)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
