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LoxP sites were inserted, with an adjacent FRT flanked neomycin resistance cassette, upstream and downstream of exon 4. Mice were subsequently mated to flp expressing mice and the offspring mated to cre expressing mice to delete, first, the selection cassette, and then exon 4. Quantitative RT-PCR from mouse brain confirmed decreased mRNA. Immunological studies confirmed the absence of protein product in the brain. (J:194266)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
