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This transgene contains a full length cDNA encoding the 04:01 variant of the beta chain of the human major histocompatibility complex (MHC) class II DP receptor (HLA-DPB1*4:01) downstream of the promoter of the mouse histocompatibility 2, class II antigen A, beta 1 (H2-Ab1) locus. The human cDNA is followed by the mouse H2-Ab1 3' noncoding sequence. Mice bearing this transgene in combination with Tg(H2-Aa-HLA-DPA1)1Lone express a human HLA-DPalpha103/DPbeta401 complex that is specifically recognized by the anti-HLA-DP monoclonal antibody B72. (J:197820)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
