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The coding sequence of the Sox2 gene in a BAC (RP23-2B8) was replaced with the coding sequence for a tamoxifen-inducible cre/estrogen receptor fusion (cre/Esr1*; CreERTM). The construct was injected into pronuclei of fertilized FVB oocytes. 3 transgene-positive founders were obtained (20, 34, and 36). Founders were bred to reporter mice, administered tamoxifen at E9.5, and embryos were analyzed for recombination activity at E10.5. Line 20 progeny displayed the strongest lacZ expression. This line was characterized further. (J:195589)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
