One loxP site was inserted 5" of exon 4. An FRT flanked neomycin selection cassette was inserted in intron 6. A second loxP site was also inserted in intron 6 downstream of the selection cassette and the selection cassette was subsequently removed from properly targeted mice by crossing to mice expressing flp recombinase leaving exons 4-6 flanked by loxP sites. Targeting was performed by inGenious Targeting Laboratory. (J:194700)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
Insertion
--
1
2
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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