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A construct (composed of cre recombinase with a nuclear localization signal, SV40 polyadenylation sequence, and an Frt-Kanamycin/neo-Frt cassette) was introduced into the ATG site in exon 2 of the Chrna2 gene in a bacterial artificial chromosome (BAC RP23-48P22) by recombineering in bacterial cells. Modified BAC DNA was purified and injected into mouse pronuclei to produce transgenic mice. One founder line showed cre expression in cells that express the CHRNA2 protein. (J:193558)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
