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The creA fragment of the cre coding sequence (codons 19-59) was fused by flexible F2 linkers to other protein motifs (human H2B and the FKBP dimerizing domain) and a polyadenylation sequence is added. This cassette was cloned into a vector such that it was under transcriptional control of a 12 kb rat Cyp1a1 promoter element. The purified construct was used for pronuclear injection to generate transgenic mice. Beta-naphthoflavone is used to induce the Cyp1a1 promoter so that cre A is produced. These mice are bred with animals expressing the creB fragment of the cre CDS. When dimerization is induced by treatment with AP20187. (J:194841)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
