The 15 nuclear hormone receptor hexad recognition sites in the ICR upstream of H19 were mutagenized to abolish protein binding. Cre-mediated recombination removes the loxP site flanked neomycin resistance gene cassette that was inserted. (J:195982)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count