The targeting vector deleted the thymic enhancer (TE) in the distal regulatory element while leaving the silencer sequence intact. A floxed neomycin selection was also inserted adjacent to the silencer element. The resistance cassette was eventually excised by transient cre expression. (J:193321)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count