A loxP site was inserted upstream of exon 1. An expression cassette (loxP site and FRT-flanked splice acceptor, IRES, EGFP and neo) was inserted into the 3' UTR. Flp-mediated recombination removed the splice acceptor, IRES, EGFP and neo. Exons 1 and 2 remain floxed. (J:194760)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count