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A loxP site was into intron 3. An FRT-flanked neo with a 3' loxP was into intron 4. Cre-mediated recombination removed the neo cassette and exon 4. RNA analysis of mammary tissue form homozygous mice detects only a mutant truncated RNA product. Immunoblot and immunohistochemical analyses confirmed the absence of protein in epidermis from homozygous mice. Depending on the antibody used a 42kDa species is detected in the thymus and prostate; however, this is thought to be the result of cross-reaction with of clade B serpins. (J:206439)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
