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EN
The final transgenic construct contained a 327-bp fragment from -290 to +37, of the human TNS4 (tensin 4; CTEN) promoter, a synthetic intron sequence, cre recombinase cDNA with a nuclear localization signal, and an SV40 polyadenylation signal. The construct was microinjected into (C57BL/6 x CBA)F1 zygotes. No founder information or line numbers are available. Crosses with reporter mice show strong cre activity in the brain and prostate, occasional staining in islets in the pancreas, bronchiole epithelium of the lung and in some tubules of the testis. No activity is observed in the kidney, small intestine, thymus, heart, tongue, liver, spleen or mammary gland. (J:195302)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
