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Exon 3 was replaced with a modified exon 3 in which nucleotide substitutions replaces a methionine with glycine at position 129 (M129G). This mutation is expected to disrupt the gatekeeper residue in the ATP-binding pocket possibly rendering the protein susceptible to small molecular analogues of the general kinase inhibitor PP1. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 2. Activity assay confirmed the sensitivity to 1NMPP1 inhibition. (J:195229)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
