A loxP site was inserted into intron 4 and an FRT flanked pgk-neo cassette and loxP site were inserted into intron 5 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 5 floxed. (J:195050)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count