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Exon 11 was replaced with a floxed neo cassette and a modified exon 11 in which the wild-type sequence is replaced with a TCTG insertion after the coding sequence nucleotide 8657 (c.854_857dupTCTG). This "conventional" mutation mimics the human mutation observed in patients with acute myeloid leukemia (AML;type A, c.860_863dupTCTG) without any "humanized" sequence. (J:194999)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
