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EN
Exon 22 was replaced with a modified version in which nucleotide substitution results in the amino acid substitution of aspartic acid with asparagine at position 892 (p.D892N) in the encoded protein. This mutation is predicted to produce a kinase dead product. The loxP site flanked neomycin resistance gene cassette that was inserted into intron 21 was removed through subsequent cre-mediated recombination. (J:195237)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
