A loxP site was inserted upstream of exon 2. Exon 3 was replaced with a modified exon 3 in which nucleotide substitution (A to T) that results in the amino acid substitution of phenylalanine for tyrosine at position 114 (Y114F). Flp-mediated recombination removed the FRT-flanked neo cassette with a 3' loxP site inserted downstream of exon 4. Exons 2 through 4 remain floxed. (J:193874)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
FVB
Targeted
Insertion, Single point
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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