A loxP site was inserted upstream of exon 1 and a FRT and loxP flanked neo cassette was inserted downstream of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:194989)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count