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The open reading frame of the bovine prion protein gene was inserted into an expression vector containing the mouse prion protein promoter, exon 1, intron 1, exon 2 and 3' untranslated region. Bovine prion protein expression in brains of homozygous transgenic mice of this line, as determined by western blot analysis, is 8-fold that observed in cow brain homogenate; none is detected in spleen, heart, skeletal muscle, testis or kidney of transgenic mice. (J:119197)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
