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This transgene contains a tetracycline response element, comprising seven copies of the 42-bp tet operator sequence, between two minimal cytomegalovirus promoters, one driving expression of the E. coli lacZ (beta-galactosidase) gene and the other of a cDNA encoding mouse secreted phosphoprotein 1 (also called osteopontin) (nt 9-955, GenBank accession BC057858). Both genes are inactive except in the presence of a second transgene expressing the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein, which permits regulation of their expression by administration/discontinuation of doxycycline. (J:159799)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
