A DsRed reporter and floxed neomycin resistance cassette was inserted in exon 2 causing a frame shift and a premature stop codon. The selection cassette was subsequently excised by cre recombination. Western blot analysis confirmed loss of gene expression. (J:192526)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count