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An FRT flanked neo cassette was inserted into intron 6 (intron 4 in the paper) and two C to G mutations were inserted into exon 7 (coding exon 6; exon 5 in the paper) via homologous recombination. These mutations replace two central prolines in the proline-rich sequence with alanines (P163A, P166A). Interaction between the mutant protein and the SH3.1 domain of Nck1 is not seen in a pull down assay. Flp mediated recombination removed the neo cassette. (J:192604)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
