A loxP site was inserted upstream of exon 2 and a an FRT flanked pgk-EM7-neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the pgk-EM7-neo cassette leaving exons 2 - 5 floxed. (J:191046)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count