A floxed neo cassette was inserted between the first upstream neuronal enhancer (nPE1) and the deleted second neuronal enhancer (nPE2). Cre-mediated recombination removed the neo cassette and restored expression in the hypothalamic arcuate nucleus (Arc). (J:194013)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count