A cassette consisting of the cre/ERT2 sequence followed by the Otx2 3' UTR with the polyadenylation signal (and floxed neo marker) replaced the entire coding sequence of Otx2 following homologous recombination in ES cells. Founder animals were bred to CMV-deleter mice to remove the neo. (J:194049)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
10
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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