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The promoter drives cardiac-specific expression of a modified cDNA in which nucleotide susbtitutions result in the amino acid substitution of methionine for lysine at position 85 (K85M) and isoleucine for lysine at position 86 (K86I). These mutations are predicted to produce a dominant negative product. Line 19 was generated. (J:142787)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
